People with a worrying cough, problems swallowing or blood in their urine will soon be able to be referred for scans and checks by a pharmacist, rather than having to wait to see their GP.
The new pilot scheme, in England, aims to diagnose more cancers early, when there is a better chance of a cure.
High Street pharmacies will be funded to refer customers for the checks.
The NHS will also send out more "roaming trucks" to perform on-the-spot scans in the community.
Lung-scanner vans driven to locations, including supermarket car parks and football stadiums, have already resulted in more people having checks.
Now, some liver lorries will join them.
About 6,100 people a year are diagnosed with liver cancer - the number has doubled over the past decade and is expected to continue to rise.